association of 1661a/g cytotoxic t lymphocyte antigen-4 (ctla-4) gene polymorphism with a clinical subset of iranian children with systemic lupus erythematosus

results our study showed that there were no statistically significant differences in the allele and genotype frequencies of -1661 a/g snp between patients with sle and healthy controls (p > 0.05). conclusions in conclusion, we found no association between snp-1661 a/g of the ctla-4 promoter region and susceptibility to sle in our population. objectives to evaluate the potential influences of common snp in ctla-4 promoter region (-1661 a/g), a case-control study was performed on iranian children. patients and methods genotypes of 31 patients and 50 healthy controls were investigated using the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. background cytotoxic t-lymphocyte antigen-4 (ctla-4) is a molecule engaged in regulation of t cells. polymorphisms in the ctla-4 gene (ctla4) are known to be associated with several autoimmune diseases, including systemic lupus erythematosus.